N-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid → HCID 14881786, compound

HRID 704425Notes

Reaction equation

HRID 704425 reaction equation
C(OC([N:8]1[CH:12]([C:13]([OH:15])=O)[CH2:11][S:10][CH:9]1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C.[ClH:22].[NH2:23][C@H:24]([C:29]([NH2:31])=[O:30])[CH2:25][CH2:26][S:27][CH3:28]>>[ClH:22].[ClH:22].[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH:9]2[NH:8][CH:12]([C:13]([NH:23][C@H:24]([C:29]([NH2:31])=[O:30])[CH2:25][CH2:26][S:27][CH3:28])=[O:15])[CH2:11][S:10]2)[CH:17]=1

Participants

3

Reactant 2

HCID 14772789N-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acidHCID 18531008(2S)-2-amino-4-(methylsulfanyl)butanamide hydrochloride

Product 1

HCID 14881786HCID 14881786, compound

Procedure

N-tert-Butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid and L-methioninamide hydrochloride were used as the starting materials and treated in the same manner as in Example 4 to give [2-(3-pyridyl)thiazolidine-4-carbonyl]-L-methioninamide dihydrochloride. Melting point 131° C.

Workup

  1. additiontreated in the same manner as in Example 4

Sources & evidence

ORD record
ord-07eced3c5eb14cb9bd1725df66553eea
Source dataset
uspto-grants-1991_01
Patent number
US04987132

Reaction notes

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