4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride → HCID 71738286, compound

HRID 70443Notes

Reaction equation

HRID 70443 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9][CH2:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15][CH3:16])=[O:14].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][C:23]=1[C:32]([F:35])([F:34])[F:33]>N1C=CC=CC=1>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:10][C:11]2[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=2[C:13]([O:15][CH3:16])=[O:14])=[C:2]([NH:1][S:28]([C:25]2[CH:26]=[CH:27][C:22]([Cl:21])=[C:23]([C:32]([F:35])([F:33])[F:34])[CH:24]=2)(=[O:30])=[O:29])[CH:7]=1

Participants

4

Reactant 2

HCID 27807194-Chloro-3-(trifluoromethyl)benzenesulfonyl ChlorideHCID 82975614Methyl 2-(((2-amino-4-chlorophenyl)thio)methyl)benzoate

Product 1

HCID 71738286HCID 71738286, compoundYield 37.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (936 mg, 37%) was prepared from methyl 2-(((2-amino-4-chlorophenyl)thio)methyl)benzoate (1.41 g, 4.56 mmol) and 4-chloro-3-(trifluoromethyl)benzene-1-sulfonyl chloride (1.3 g, 4.56 mmol) in pyridine (10 ml).

Sources & evidence

ORD record
ord-98617426dec14e3dbfcdc1a408708aaa
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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