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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 704437Generated: October 30, 2026

1-(3-Phenylpropyl)piperazine → 1-[3-(Tert-butoxycarbonyl)-2-(3 pyridyl)thiazolidin-4-ylcarbonyl]-4-(3-phenylpropyl)piperazine

https://huagongshe.com/reaction/704437

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Phenylpropyl)piperazineHCID 796534—
ReactantN-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acidHCID 14772789—
Product1-[3-(Tert-butoxycarbonyl)-2-(3 pyridyl)thiazolidin-4-ylcarbonyl]-4-(3-phenylpropyl)piperazineHCID 1488156057.6%

Reaction Steps

3-tert-Butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid (650 mg) and 1-(3-phenylpropyl)piperazine (400 mg) were used as the starting materials and treated in the same manner as in Example 54. Without conversion to the hydrochloride, the product was purified by silica gel column chromatography (eluent ethyl acetate) Thus was obtained 1-[3-(tert-butoxycarbonyl)-2-(3 pyridyl)thiazolidin-4-ylcarbonyl]-4-(3-phenylpropyl)piperazine (560 mg) as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04987132
Source datasetuspto-grants-1991_01
ORD IDord-4e3f4b96bcc44ca6844dafa91291f264
Source noteuspto-grants-1991_01