HCID 20074099, compound → HCID 14881783, compound

Participants

Reaction Steps

1-Heptyl-4-[2-(3-pyridyl)-2-pyrrolin-5-ylcarbonyl]piperazine (570 mg) was catalytically reduced in 20 ml of water plus 20 ml of ethanol in the presence of platinum oxide as the catalyst until cessation of the absorption of hydrogen. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the residue was subjected to silica gel column chromatography (5 g). Elution with methanol ethyl acetate (1:10, v/v) gave 250 mg of 1-heptyl-4-[5-(3-pyridyl)pyrrolidin-2-ylcarbonyl]piperazine. This product was converted to its trihydrochloride (180 mg) in the same manner as in Example 54. Melting point 138°-143° C.

Provenance & Evidence