反应详情

2.35 g (10 mmol) of 4,5-bischloromethyl veratrol was added at room temperature to a suspension comprising 5 ml of a 50% sodium hydroxide aqueous solution, 25 ml of toluene, 1.25 g (11.66 mmol) of benzylamine and 0.2 g of a Starks catalyst. The mixture was stirred at room temperature for 20 hours, and then the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the crystalline residue was washed with isopropyl ether to obtain 1.87 g (yield: 70.0%) of the above identified compound as colorless needle-like crystals.

1. customthe organic layer was separated
2. dry with materialdried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. washthe crystalline residue was washed with isopropyl ether
5. customto obtain 1.87 g (yield: 70.0%) of the