2-Benzyl-5,6-dimethoxyisoindoline → 5,6-Dimethoxyisoindoline

HRID 704457Notes

Reaction equation

HRID 704457 reaction equation
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:19][CH3:20])=[C:13]([O:17][CH3:18])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[O:19][CH3:20])[CH2:9][NH:8][CH2:16]2

Participants

4

Reactant 1

HCID 149937372-Benzyl-5,6-dimethoxyisoindoline

Product 1

HCID 200743515,6-DimethoxyisoindolineYield 77.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.20 g (4.46 mmol) of 2-benzyl-5,6-dimethoxyisoindoline was dissolved in 40 ml of methanol at 40° C., and 84 mg of 10% palladium carbon was added thereto. Under a hydrogen stream, catalytic reduction was conducted at the same temperature for 4 hours. The solvent was distilled off under reduced pressure, and a small amount of ethyl acetate and diethylether was added to the residue and stirred. The precipitates were collected to obtain 617 mg (yield: 77.3%) of the above identified compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. additiona small amount of ethyl acetate and diethylether was added to the residue
  3. customThe precipitates were collected
  4. customto obtain 617 mg (yield: 77.3%) of the

Sources & evidence

ORD record
ord-ad7730c17b25490ab447e050783a9c6c
Source dataset
uspto-grants-1991_01
Patent number
US04987235

Reaction notes

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