反应详情

1.20 g (4.46 mmol) of 2-benzyl-5,6-dimethoxyisoindoline was dissolved in 40 ml of methanol at 40° C., and 84 mg of 10% palladium carbon was added thereto. Under a hydrogen stream, catalytic reduction was conducted at the same temperature for 4 hours. The solvent was distilled off under reduced pressure, and a small amount of ethyl acetate and diethylether was added to the residue and stirred. The precipitates were collected to obtain 617 mg (yield: 77.3%) of the above identified compound.

1. distillationThe solvent was distilled off under reduced pressure
2. additiona small amount of ethyl acetate and diethylether was added to the residue
3. customThe precipitates were collected
4. customto obtain 617 mg (yield: 77.3%) of the