HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Flumiclorac-pentyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3,4,5,6-Tetrahydrophthalic anhydride | HCID 12475 | — |
| Reactant | 4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline | HCID 14617850 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Flumiclorac-pentyl | HCID 443048 | 95.1% |
Reaction Steps
A mixture of the compound (II) (12.0 g), 3,4,5,6-tetrahydrophthalic anhydride (7.56 g), piperidine (0.36 g), acetic acid (0.5 g) and toluene (24 g) was refluxed at 88° to 92° C. under a pressure of about 300 mmHg for 4 hours, during which water was azeotropically removed. The reaction mixture was then treated as in Example 4 to give the compound (I) (16.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04987247 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-956d1aa9e0b14fc297b7a1a378834c15 |
| Source note | uspto-grants-1991_01 |