HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4,5,6-Tetrahydrophthalic anhydride → Flumiclorac-pentyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4,5,6-Tetrahydrophthalic anhydride | HCID 12475 | — |
| Reactant | 4-Chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline | HCID 14617850 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Flumiclorac-pentyl | HCID 443048 | 62.1% |
Reaction Steps
A mixture of the compound (II) (12.0 g), 3,4,5,6-tetrahydrophthalic anhydride (7.56 g) and toluene (50 g) was heated under reflux for 12 hours. Analysis by high speed liquid chromatography revealed the presence of 20% of the compound (II) as unreacted. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give the compound (I) (10.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04987247 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-b8306121b4204b128c7a72a2a0ab38b0 |
| Source note | uspto-grants-1991_01 |