反应详情

In 200 ml of ethanol was dissolved 12 g of 2-acetoxymethyl7-chloro-5-methoxycarbonyl-s-triazolo[1,5-a]pyrimidine under heating, and 8.36 g of thiourea was added to the solution and the mixture was stirred under reflux for 10 minutes. After cooling by allowed to stand, precipitates were collected by filtration, washed with ethanol and then dissolved in 100 ml of a 10 % KOH, and the solution was stirred at room temperature for one hour. This solution was adjusted to pH 1 with 2N HCl under ice-cooling and stirring, and precipitates were collected by filtration, washed with water and then dried to obtain 8.13 g of the title compound.

1. temperatureunder heating
2. temperatureunder reflux for 10 minutes
3. temperatureAfter cooling
4. customprecipitates
5. filtrationwere collected by filtration
6. washwashed with ethanol
7. dissolutiondissolved in 100 ml of a 10 % KOH
8. stirringthe solution was stirred at room temperature for one hour
9. temperaturecooling
10. stirringstirring
11. customprecipitates
12. filtrationwere collected by filtration
13. washwashed with water
14. customdried