Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 178432391 | HCID 178432391 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178475878 | HCID 178475878 | — |
Reaction Steps
A mixture of 33.06 g of 7-hydroxy-5-hydroxymethyl-2-methyl-s-triazolo[1,5-a]pyrimidine, 500 ml of DMF, 86 ml of anhydrous acetic acid and 1.5 g of p-toluenesulfonic acid was stirred in a bath at 50 ° C. for 6 hours. To an oily isopropanol to dissolve therein, and the solution was dropwise in 4 liters of ether. Precipitates were collected by filtration and dried to obtain 38.08 g of the compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04987129 |
|---|
| Source dataset | uspto-grants-1991_01 |
|---|
| ORD ID | ord-b08ce1cfa1334cc4946ef42ab590d8bf |
|---|
| Source note | uspto-grants-1991_01 |
|---|
