反应详情

A solution of sodium methoxide (from 1.2 g sodium in 25 ml methanol) was added dropwise over 2 hours to a refluxing solution of methyl-3-phenoxybenzoate (11 g) in acetonitrile (100 ml) under a nitrogen atmosphere while distilling off methanol and excess acetonitrile. After complete removal of methanol the reaction mixture was poured onto ice-water (200 g) and acidified with 50% HCl. The solid was filtered off and dried to give the title compound (7.5g, 65%) as a white solid of m.p. 95°-96° C.

1. distillationwhile distilling off methanol and excess acetonitrile
2. customAfter complete removal of methanol the reaction mixture
3. additionwas poured onto ice-water (200 g)
4. filtrationThe solid was filtered off
5. customdried