HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium borohydride → (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium borohydride | HCID 4148881 | — |
| Edukt | (4S)-5-(tert-butoxy)-4-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid | HCID 6993444 | — |
| Edukt | Z-Glu-OtBu | HCID 6994036 | — |
| Produkt | (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate | HCID 4055117 | — |
Reaktionsschritte
Cbz-Glu-OtBu 51 is converted to 52 via the methyl ester followed by LiBH4 reduction according to the procedure of Y. Hamada, M. Shibata, T. Sugiura, S. Kato and T. Shioiri, J. Org. Chem. 52:1242, 1987 used for the conversion of t-Boc-Glu-OtBu to the corresponding alcohol.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04988496 |
| Quelldatensatz | uspto-grants-1991_01 |
| ORD ID | ord-6fd5b1239ca04a35b76e2134e474c8c9 |
| Quellennotiz | uspto-grants-1991_01 |