Chloroform → HCID 15623851, compound

HRID 704560Notes

Reaction equation

HRID 704560 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([Cl:10])[C:7]([NH2:11])=[C:6]([Br:12])[CH:5]=1)(=[O:3])[CH3:2].C(Cl)(Cl)[Cl:14]>>[NH2:11][C:7]1[C:8]([Cl:10])=[N:9][C:4]([C:1](=[O:3])[CH2:2][Cl:14])=[CH:5][C:6]=1[Br:12]

Participants

3

Reactant 2

HCID 6212Chloroform2×HCID 15623852HCID 15623852, compound

Product 1

HCID 15623851HCID 15623851, compound

Procedure

0.8 g (3.2 mmol) of 6-acetyl-3-amino-4-bromo-2-chloro-pyridine are dissolved in 5 ml of CHCl3, and 462 mg (3.42 mmol) of SO2Cl2, dissolved in 5 ml of CHCl3, are added. The mixture is stirred at room temperature for 30 minutes and then poured onto NaHCO3 solution and extracted with CH2Cl2.

Workup

  1. additionare added
  2. additionpoured onto NaHCO3 solution
  3. extractionextracted with CH2Cl2

Sources & evidence

ORD record
ord-fb1efad3ca15412e95e539ee2ed587f3
Source dataset
uspto-grants-1991_01
Patent number
US04988694

Reaction notes

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