HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazole-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-amino-4,5,6,7-tetrahydro-1,3-benzothiazole-6-carboxylate | HCID 15101120 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazole-6-carboxylic acid | HCID 15101103 | — |
Reaction Steps
A solution of (±)-methyl 2-amino-4,5,6,7-tetrahydro-6-benzothiazolecarboxylate (8.5 g) (Example D) in 200 ml of 2N sulfuric acid is refluxed for eight hours. The solution is cooled in ice and adjusted to pH 6 with concentrated sodium hydroxide solution. The title compound precipitates as a beige solid; mp 220°-250° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04988699 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-683db2d7ffdb424da3396a35be2997c7 |
| Source note | uspto-grants-1991_01 |