Hydrochloric Acid → HCID 86744541, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl (Z)-8-dibutylamino-2-(ethoxyisobutylphosphinoyl)methyl-2-octenoate (200 mg; 0.43 millimole) was dissolved in 5 ml of concentrated hydrochloric acid, and the solution was stirred at 90° C. for 5.5 hours. After cooling, the reaction mixture was concentrated under reduced pressure. The residue was purified by medium-pressure liquid chromatography [Lobar column (a product of E. Merck & Co.), size B, Lichroprep RP-18, methanol/water (7:3)] to give 178 mg (yield 94%) of the captioned compound as a pale yellow oil.

Provenance & Evidence