反应详情

A solution of 107 mg (0.31 millimole) of ethyl (Z)-3-cyclohexyl-2-(ethoxyisobutylphosphinoyl)methylpropenoate in 1.0 ml of 4N HCl-butyl acetate was heated in a sealed tube at 100° C for 2 hours. After cooling, the solvent was evaporated under reduced pressure, and the residue was purified by "dry-column" flash chromatography 15 g of silica gel 60 made by E. Merck & Co.; chloroform-methanol-acetic acid (50:1:1)] to give 91 mg (yield 94%) of the captioned compound as a colorless oil.

1. temperatureAfter cooling
2. customthe solvent was evaporated under reduced pressure
3. customthe residue was purified by "dry-column" flash chromatography 15 g of silica gel 60