Acetic Anhydride → HCID 14760614, compound

HRID 704650Notes

Reaction equation

HRID 704650 reaction equation
[CH:1]([C:3]1[N:8]=[CH:7][CH:6]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[C:5](=[O:19])[CH:4]=1)=[O:2].[C:20](OC(=O)C)(=[O:22])[CH3:21]>N1C=CC=CC=1.C(Cl)Cl>[C:20]([O:19][C:5]1[CH:4]=[C:3]([CH:1]=[O:2])[N:8]=[CH:7][C:6]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)(=[O:22])[CH3:21]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 72739010HCID 72739010, compound

Product 1

HCID 14760614HCID 14760614, compoundYield 547.3%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.05 g of 6-formyl-3-(p-methoxybenzyl)oxy-4-pyridone in 5 ml of pyridine is added 0.133 g of acetic anhydride, and the mixture is stirred for 2 hours. The reaction mixture is condensed under reduced pressure, and the residue is dissolved in 20 ml of methylene chloride, washed with water, 5% aqueous potassium hydrogen sulfatge solution and 7% aqueous sodium hydrogen carbonatge solution in this sequence, dried over magnesium sulfate, and condensed to dryness under reduced pressure to give 0.318 g of the title compound as colorless crystal.

Workup

  1. customcondensed under reduced pressure
  2. washwashed with water, 5% aqueous potassium hydrogen sulfatge solution and 7% aqueous sodium hydrogen carbonatge solution in this sequence
  3. dry with materialdried over magnesium sulfate, and condensed to dryness under reduced pressure

Sources & evidence

ORD record
ord-ded095cfec864ffba23a42083baf5c23
Source dataset
uspto-grants-1991_01
Patent number
US04988686

Reaction notes

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