N,N-Dimethylethylenediamine → 3-Diphenylmethoxy-1-(2-dimethylaminoethyl)-6-hydroxymethyl-4-pyridone

Participants

Reaction Steps

To a suspension of 1.542 g of 6-hydroxymethyl-3-(p-methoxybenzyl)oxy-4-pyridone in 10 ml of methanol is added 4.408 g of N,N-dimethylethylenediamine, and the mixture is stirred for 14 hours. The reaction mixture is condensed under reduced pressure, and subjected to flash column chromatography on 50 g of Wako-Gel C-300 (manufactured by Wako Pure Chemical Industries, Ltd.) with an eluent of chloroform-methanol (10:1) to perform separation and purification. The title compound is obtained as colorless crystal in a yield of 1.174 g.

Provenance & Evidence