3-Diphenylmethoxy-1-(2-dimethylaminoethyl)-6-hydroxymethyl-4-pyridone → 3-Diphenylmethoxy-1-(2-dimethylaminoethyl)-6-formyl-4pyridone

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Reaction Steps

To a solution of 1.160 g of 3-diphenylmethoxy-1-[2(dimethylamino)ethyl]-6-hydroxymethyl-4-pyridone is added 6.0 g of manganese dioxide at room temperature, and the mixture is stirred for 3 hours. Insolubles are removed by filtration, and the filtrate was subjected to flash column chromatography on 50 g of Wako-Gel C-300 (manufactured by Wako Pure Chemical Industries, Ltd.) with an eluent of chloroform-methanol (10:1) to perform separation and purification. The title compound is obtained as colorless crystal in a yield of 0.744 g.

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