Isopropylamine → HCID 15058196, compound

Participants

Reaction Steps

To a solution of 3.083 g of 3-diphenylmethoxy-6-hydroxymethyl-4-pyridone in 120 ml of methanol is added 11.082 g of isopropylamine at room temperature, and the mixture is stirred for 6 days. The reaction mixture is condensed to dryness under reduced pressure, and the resulting residue is subjected to flash column chromatography on 120 g of Wako-Gel C-300 (manufactured by Wako Pure Chemical Industries, Ltd.) with an eluent of chloroform-methanol (20:1) to perform separation and purification. The title compound (1.608 g) is obtained as colorless crystal.

Provenance & Evidence