Methanol → HCID 15058197, compound

Participants

Reaction Steps

To a methanol solution (120 ml) of 1.600 g of 3-diphenylmethoxy-6-hydroxymethyl-1-isopropyl-4-pyridone is added 10.00 g of active manganese dioxide at room temperature, and the mixture is stirred for 5 hours, then at 50° C. for 1 hour. After insolubles are removed by filtration, the filtrate is condensed under reduced pressure and the residue is subjected to flash column chromatography on 100 g of Wako-Gel C-300 (manufactured by Wako Pure Chemical Industries, Ltd.) with an eluent of benzene-ethyl acetate (1:2) to perform separation and purification. The title compound (0.862 g) is obtained as colorless foam.

Provenance & Evidence