HCID 20072687, compound → HCID 20072712, compound

Participants

Reaction Steps

To a solution of 2.391 g of 3-diphenylmethyl-6-hydroxymethyl-1-(4-pyridyl)methyl-4-pyridone in 150 ml of methanol is added 14.0 g of active manganese dioxide at room temperature, and the mixture is stirred for 30 minutes. After insolubles are removed by filtration, the filtrate is subjected to flash column chromatography on 100 g of Wako-Gel C-300 (manufactured by Wako Pure Chemical Industries, Ltd.) with an eluent of chloroform-methanol (20:1) to perform separation and purification. The title compound (2.043 g) is obtained as colorless foam.

Provenance & Evidence