Potassium Carbonate → HCID 14279659, compound

Participants

Reaction Steps

A mixture of 2-chloro-5-chloromethylpyridine (3.24 g), 2-cyanaminopyrimidine(2.4 g), anhydrous potassium carbonate (3.04 g) and acetonitrile (100 ml) was refluxed for 5 hours under stirring. About 50 ml of the acetonitrile were evaporated under reduced pressure, and the residue was poured into ice water. The precipitated crystals were collected by filtration, and recrystallized from ethanol to give 1-(2-chloro-5-pyridylmethyl)-2-cyanoimino-1,2-dihydropyrimidine (1.87 g) as colorless crystals. mp. 218°-220° C.

Provenance & Evidence