Dimethylacetamide → HCID 9905120, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example G (270 mg, 0.0011 moles) was dissolved in 5 mls of dimethylacetamide containing 135 mg (0.0011 moles) of 1H-imidazo[4,5-c]pyridine and stirred under nitrogen at 80° C. for 24 hours and at 115° C. for an additional 6 hours. The reaction appeared to be complete by TLC. After cooling, the solvent was removed by vacuum distillation. Chromatography of the crude product (twice) on silica gel using CH3OH/CH2Cl2 /NH4OH (5/95/1) as the eluent gave 200 mg (57%) of the title compound as a monohydrate m.p.=153°-156° C.

Provenance & Evidence