HCID 15158221, compound → HCID 15158231, compound

HRID 704699Notes

Reaction equation

HRID 704699 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:20])[CH:10]([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:11][CH:12]=[CH2:13])=[CH:5][CH:4]=1.[NH:21]1[C:29]2[CH:28]=[CH:27][N:26]=[CH:25][C:24]=2[N:23]=[CH:22]1>>[CH:14]1([CH:10]([CH2:11][CH:12]=[CH2:13])[C:9]([C:6]2[CH:7]=[CH:8][C:3]([CH2:2][N:26]3[CH:27]=[CH:28][C:29]4=[N:21][CH:22]=[N:23][C:24]4=[CH:25]3)=[CH:4][CH:5]=2)=[O:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 15158221HCID 15158221, compoundHCID 178419860HCID 178419860, compound

Product 1

HCID 15158231HCID 15158231, compoundYield 60%

Procedure

Following the procedure of Example 1, 85mg (0.00029 moles) of the product of Example Q was reacted with 35mgs of 1H-imidazo[4,5-c]pyridine. The crude product was chromatographed on silica gel using MeOH/CH2Cl2/ NH4OH (5/94/1) as eluent to give 65 mg (60% yield) of the title compound.

Workup

  1. customThe crude product was chromatographed on silica gel

Sources & evidence

ORD record
ord-3d10ce1f29ad4859ae649e11f7f9328d
Source dataset
uspto-grants-1991_01
Patent number
US04988707

Reaction notes

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