Water → HCID 178460455, compound

HRID 704754Notes

Reaction equation

HRID 704754 reaction equation
[CH2:1]([CH:3]1[C:7]2=[N:8][C:9]3[C:10]([C:17]([F:20])([F:19])[F:18])=[CH:11][CH:12]=[CH:13][C:14]=3[C:15]([OH:16])=[C:6]2[C:5](=[N:21][C:22]2[S:23][CH:24]=[CH:25][N:26]=2)[O:4]1)[CH3:2].[OH2:27]>C(O)(=O)CC>[OH:16][C:15]1[C:14]2[C:9](=[C:10]([C:17]([F:20])([F:19])[F:18])[CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([CH:3]([O:27][C:3](=[O:4])[CH2:1][CH3:2])[CH2:1][CH3:2])[C:6]=1[C:5]([NH:21][C:22]1[S:23][CH:24]=[CH:25][N:26]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 1784381861,3-Dihydro-3-ethyl-1-[(2-thiazolyl)-imino]-5-trifluoromethyl-furo[3,4-b]quinoline-9-ol

Product 1

HCID 178460455HCID 178460455, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

A suspension of 3 g of 1,3-dihydro-3-ethyl-1-[(2thiazolyl)-imino]-5-(trifluoromethyl)-furo-[3,4-b]-quinolin-9-ol in 60 ml of propionic acid was held in a bath at 100°-110° C. for 2 hours and 50 minutes and the solution obtained was cooled and poured into 600 ml of water. After separating and washing with water, 2.5 g of product were obtained which was purified by crystallization from 40 ml of ethyl acetate. The crystals were cooled and recovered by filtration to obtain 1 7 g of 4-hydroxy-2-[1-(1-oxopropoxy)-propyl] -N-(2-thiazolyl)-8-(trifluoromethyl)-3-quinoline carboxamide melting at 216° C.

Workup

  1. customthe solution obtained
  2. temperaturewas cooled
  3. customAfter separating
  4. washwashing with water

Sources & evidence

ORD record
ord-6910ed2f813247f9a7362867a9add54f
Source dataset
uspto-grants-1991_01
Patent number
US04988708

Reaction notes

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