Sodium hydride → HCID 20073264, compound

Participants

Reaction Conditions

Reaction Steps

60% Dispersion of sodium hydride (0.40 g) in mineral oil was added in small portion at ambient temperature to a solution of 2-cyanoimino-1-ethylimidazolidine (1.38 g) in dimethyl sulfoxide (15 ml). The reaction mixture was stirred for 30 minutes at the same temperature, and 3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (1.01 g) was added thereto. The reaction mixture was stirred overnight at the same temperature, heated for 1.5 hours at 40° C., and then poured into ice-water (50 ml). The forming precipitate was collected by filtration, and washed with water. The product was recrystallized from ethanol to give 4-(2-cyanoimino-3-ethylimidazolidin-1-yl)-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (0.36 g).

Provenance & Evidence