Dimethylamine → HCID 178484319, compound

Participants

Reaction Steps

A mixture of (3S,4R)-4-(3-cyano-2-methyl-1-isothioureido)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (16.3 g) and 50% aqueous dimethylamine solution (81.5 ml) was stirred under reflux for 1.5 hours to form white precipitates. These precipitates were collected by filtration, washed with cold water, and recrystallized from ethanol to give (3S,4R)-4-(2-cyano-3,3-dimethylguanidino)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (12.05 g).

Provenance & Evidence