(1aS,7bS)-2,2-Dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-carbonitrile → trans-4-(2-cyanoiminothiazolidin-3-yl)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Beteiligte Stoffe

Reaktionsschritte

A mixture of (3S,4S)-3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (0.603 g) and 2 -cyanoiminothiazolidine (0.762 g) in triethylamine (4.2 ml) was heated under reflux for 9 hours. The resulting precipitates were collected by filtration, and washed with water, and recrystallized from ethanol to give (3S,4R)-4(2-cyanoiminothiazolidin-3-yl)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (0.56 g).

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