N-(4-((oxiran-2-yl)methoxy)phenyl)acetamide → (RS)-6-chloro-alpha-[[[(R)-p-(2-ethoxyethoxy)-alpha-methylphenethyl]amino]methyl]-2-pyridinemethanol

Participants

Reaction Steps

using 4'-(2,3-epoxypropoxy)acetanilide there were obtained from 1.0 g of (RS)-6-chloro-α-[[[(R)-p-(2-ethoxyethoxy)-α-methylphenethyl]amino]methyl]-2-pyridinemethanol (Example 4C) 530 mg of 4'-[(RS)-3-[[(RS)-2-(6-chloro-2-pyridyl)-2-hydroxyethyl][(R)-p-(2-ethoxyethoxy)-α-methylphenethyl]amino]-2-hydroxypropoxy]acetanilide, [α]D20° =-39` (c=0.4 in MeOH),

Provenance & Evidence