Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline | HCID 383961 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Imiquimod | HCID 57469 | — |
Reaction Steps
A solution of 4-chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (0.86 g) in 7 g of a methanol solution containing 20% by weight of ammonia was placed in a steel bomb for 20 h at 150° C. After cooling to 20° C., the solid formed was collected by filtration and washed with methanol. The crude product 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine was recystallized from N,N-dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04988815 |
|---|
| Source dataset | uspto-grants-1991_01 |
|---|
| ORD ID | ord-d8302b7d2a5a40b9aae7a8c8add5e954 |
|---|
| Source note | uspto-grants-1991_01 |
|---|
