Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline | HCID 383961 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Imiquimod | HCID 57469 | 70% |
Reaction Steps
A mixture of 4-chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (66 g), methanol (266 mL) and ammonia (46.2 g) was placed in a steel bomb and heated at 150° C. for 8 h. The resulting mixture was filtered, and the solid was washed with water and dried to afford the product 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine in 70% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04988815 |
|---|
| Source dataset | uspto-grants-1991_01 |
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| ORD ID | ord-098f76c29f7249659ee219f0bdbcf59e |
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| Source note | uspto-grants-1991_01 |
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