HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isatoic Anhydride → HCID 13365992, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isatoic Anhydride | HCID 8359 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-(4-pyrimidin-2-ylpiperazin-1-yl)propan-1-amine | HCID 10704227 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13365992 | HCID 13365992 | — |
Reaction Steps
0.02 mol of 1-(3-aminopropyl)-4-(2-pyrimidinyl)piperazine is dissolved in 100 ml of absolute dimethylformamide, 0.02 mol of isatoic anhydride is added, and the mixture is stirred for 1 hour. It is diluted with 50 ml of water, shaken with ethyl acetate and the organic phase is evaporated. Purification is by column chromatography over silica gel 60. After elution with methylene chloride/methanol 93:7, the resulting oil can be crystallised from ethyl acetate with isopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04988809 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-6a80879adfb644f3bf448249e05f947c |
| Source note | uspto-grants-1991_01 |