HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2,2-Dimethylpropanoic acid 3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propan-1-ol | HCID 410901 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,2-Dimethylpropanoic acid 3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl ester | HCID 10914620 | — |
Reaction Steps
To a stirred solution of 3-[4-(2-methoxyphenyl)-1-piperazinyl]propanol (4.76 g, 0.019 mol) and triethylamine (6 g, 0.06 mol) in 100 mL of methylene chloride was added pivaloyl chloride (2.28 g, 0.019 mol) and stirring was continued overnight at room temperature. The organic layer was washed with water, dried (anhydrous Na2SO4) and evaporated. The title compound was isolated by preparative HPLC and converted to the dihydrochloride salt; mp.=202°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04988814 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-f9e39fef97454ea6b6dfa957bde64076 |
| Source note | uspto-grants-1991_01 |