反应详情

Formic acid (6.90 g, 0.15 mol) was added to acetic anhydride (15.30 g, 0.15 mol) and warmed to 45°-50° C. for one hour on a water bath. The resulting solution was cooled to below 0° C. in an ice/acetone bath. 3-Formamido-3-methyl-1-butanol (13.10 g, 0.10 mol) was added and the solution allowed to slowly warm to room temperature with stirring (16 hours). The solution was distilled under vacuum (1 Torr, 105°-110° C.) to yield 12.43 g (78%).

1. temperaturewarmed to 45°-50° C. for one hour on a water bath
2. temperatureThe resulting solution was cooled to below 0° C. in an ice/acetone bath
3. distillationThe solution was distilled under vacuum (1 Torr, 105°-110° C.)
4. customto yield 12.43 g (78%)