3-[3-(1,3-Dioxolan-2-yl)phenoxy]propanamine → N-{3-[3-(1,3-dioxolan-2-yl)phenoxy]propyl}-2-(furfurylsulfinyl)acetamide

Participants

Reaction Steps

3-[3-(1,3-dioxolan-2-yl)phenoxy]propylamine (16.3 g) was dissolved in 400 ml of methylene chloride, and p-nitrophenyl 2-(furfurylsulfinyl)acetate (22.58 g) was added little by little. The mixture was stirred at room temperature for 18 hours. The organic layer was washed successively with a 1N aqueous NaOH solution and water and dried over anhydrous magnesium sulfate. The solvent was evaporated to give 21.29 g (yield 74%) of N-{3-[3-(1,3-dioxolan-2-yl)phenoxy]propyl}-2-(furfurylsulfinyl)acetamide.

Provenance & Evidence