HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → [3-(3-Aminopropoxy)phenyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-{3-[3-(Hydroxymethyl)phenoxy]propyl}-1H-isoindole-1,3(2H)-dione | HCID 12780082 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [3-(3-Aminopropoxy)phenyl]methanol | HCID 14025829 | 52.1% |
Reaction Steps
N-[3-(3-hydroxymethylphenoxy)propyl]phthalimide (16 g) was dissolved in 300 ml of methanol, and 5 g of hydrazine hydrate was added. The mixture was refluxed for 5 hours, and after cooling, the insoluble matter was removed by filtration. The filtrate was concentrated to give 4.85 g (yield 52.1%) of 3-(3-hydroxymethylphenoxy)propylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04988828 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-072481ced7fb44e3825c5e2bb917cf92 |
| Source note | uspto-grants-1991_01 |