反应详情

温度

65 °C

Manganese dioxide (8.34 g) was added to a solution of (5-chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanol (1.42 g) in chloroform (40 mL), and the mixture was stirred at 65° C. for one hour. The reaction solution was filtered through celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1) to give the title compound as a yellow powder (1.02 g, 71%).

1. filtrationThe reaction solution was filtered through celite
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1→1:1)