Dimethylformamide → 2-{6-[3-(pyridin-3-yl)-1H-pyrazol-1-yl]pyridin-2-yl}pyrimidine

Participants

Reaction Conditions

Reaction Steps

10 ml of DMF were added to 515.5 mg (3.55 mmol) of 3-(1H-pyrazol-3-yl)pyridine (preparation cf. WO 94/29300 A1), 838.5 mg (3.55 mmol) of 2-(6-bromopyridin-2-yl)pyrimidine (WO 2010/006713), 28.2 mg (0.35 mmol) of copper(II) oxide, 2.31 g (7.10 mmol) of cesium carbonate and 276.3 mg (1.06 mmol) of iron(III) acetylacetonate, and the mixture was stirred at 90° C. for 60 hours. The entire reaction mixture was then cooled to room temperature, and water was added. The reaction mixture was then extracted with ethyl acetate. The organic phase was separated off, dried and concentrated under reduced pressure. The residue was purified by chromatography on silica gel. This gave 334 g (31.3% of theory) of 2-{6-[3-(pyridin-3-yl)-1H-pyrazol-1-yl]pyridin-2-yl}pyrimidine.

Provenance & Evidence