2-(Aminomethyl)-5-methylpyrazine → HCID 46834866, compound

HRID 705103Notes

Reaction equation

HRID 705103 reaction equation
[CH:1]([C:4]1[C:5]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=3)[CH:17]=2)[C:12](O)=[O:13])=[N:6][S:7][N:8]=1)([CH3:3])[CH3:2].[CH3:25][C:26]1[N:27]=[CH:28][C:29]([CH2:32][NH2:33])=[N:30][CH:31]=1>>[CH:1]([C:4]1[C:5]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=3)[CH:17]=2)[C:12]([NH:33][CH2:32][C:29]2[CH:28]=[N:27][C:26]([CH3:25])=[CH:31][N:30]=2)=[O:13])=[N:6][S:7][N:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27564962-(Aminomethyl)-5-methylpyrazineHCID 59370282HCID 59370282, compound

Product 1

HCID 46834866HCID 46834866, compound

Procedure

Following the procedure of step 4 of Example 1, 3-(4-isopropyl-[1,2,5]thiadiazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid was reacted with C-(5-methyl-pyrazin-2-yl)-methylamine to afford 3-(4-isopropyl-[1,2,5]thiadiazol-3-yl)-N-(5-methyl-pyrazin-2-ylmethyl)-5-(5-methyl-pyridin-2-yl)-benzamide, MS (M+H)=445.

Sources & evidence

ORD record
ord-7256a2fdd23d4d5c97e68b72239b22ff
Source dataset
uspto-grants-2015_11
Patent number
US09173861B2

Reaction notes

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