3-(Trifluoromethyl)phenyl isocyanate → HCID 18613735, compound

HRID 705116Notes

Reaction equation

HRID 705116 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[CH:11][N:10]=[C:9]2[CH:15]([NH:17][CH3:18])[CH3:16])=[CH:4][CH:3]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23]([N:27]=[C:28]=[O:29])[CH:24]=[CH:25][CH:26]=1>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[CH:11][N:10]=[C:9]2[CH:15]([N:17]([CH3:18])[C:28]([NH:27][C:23]2[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:30])([F:31])[F:19])[CH:22]=2)=[O:29])[CH3:16])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 18613744HCID 18613744, compound

Product 1

HCID 18613735HCID 18613735, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The amine (26) (12 mg, 0.05 mmol) and 3-trifluoromethylphenyl isocyanate (7.5 L, 0.05 mmol) were dissolved in chloroform (0.2 mL) and stirred at ambient temperature. After complete conversion of the starting material by TLC analysis, the solvent was removed and the resulting residue was subjected to silica-gel column chromatography [eluent: Dichloromethane] to give the title urea (27) (14 mg, quant.) as a solid:

Workup

  1. customAfter complete conversion of the starting material by TLC analysis, the solvent was removed

Sources & evidence

ORD record
ord-322bbbd5dec3447a864d7ce4addd96aa
Source dataset
uspto-grants-2015_11
Patent number
US09173869B2

Reaction notes

Loading…