Maleic Acid → HCID 178441802, compound

Participants

Reaction Conditions

Reaction Steps

5-Butyl-3-(6-(pyrrolidin-1-yl)hexyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine (205 mg) was treated with maleic acid (34.5 mg, 0.5 eq) before being slurried in IPA (2.0 mL). The resulting reaction mixture was heated to 70° C. resulting in a homogeneous solution which on aging at 70° C. started to precipitate solid. The resulting slurry was found to set solid after 30 mins at 70° C. therefore additional IPA (0.5 mL) was added to mobilise the slurry. The resulting reaction mixture was allowed to cool to 20° C. and was aged overnight at 20° C. before being filtered and washed with fresh IPA (2×4 mL) to yield a white solid which was oven dried at 40° C. in vacuo (90 mbar) overnight. The resulting solid (199 mg) was further dried in vacuo at 50° C. to afford the title compound.

Provenance & Evidence