Diclofensine → Tartrate

Participants

Role	Name	HCID	Charge
Reactant	Diclofensine	HCID 68871	—
Reactant	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—
Product	Tartrate	HCID 119400	—
Product	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—

Reaction Steps

The L-tartrate of the (˜)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline was prepared using (+4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline following similar steps described for the synthesis of the (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-tartrate salt ([α]24D −6.0° (c 0.10, methanol)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09173879B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-d28738c633f744a586f214d51c6b08d1
Source note	uspto-grants-2015_11