HCID 71256870, compound → HCID 86700494, compound

Participants

Reaction Steps

Compound 9 (61 mg, 0.14 mmol, 1 equiv.) was dissolved in N2-sparged tetrahydrofuran (THF, 10 mL) prior to addition of concentrated HCl (0.8 mL) and N2-sparged deionized water (8 mL). The reaction mixture was stirred for one hour prior to the addition of an additional 8 mL DI H2O. After 15 min, the THF was removed under vacuum, and the precipitate that formed was collected via filtration and rinsed with DI H2O. To remove residual starting material, the crude product was precipitated from diethyl ether to yield 49 mg (73%) of a white powder. 1H NMR (400 MHz, d6-Acetone): δ5.27 (2H, s), 7.22 (2H, s), 7.45 (2H, d, J=8.0 Hz), 7.80 (1H, dd, J=9.4, 2.2 Hz), 7.92 (2H, d, J=8.4 Hz), 8.17 (1H, d, J=9.6 Hz), 8.63 (1H, d, J=2.0 Hz).

Provenance & Evidence