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HRID705204

反应详情

EQUATION

反应方程式

HRID 705204 的结构方程式

REACTANTS

反应物

3
结构：CC(C)OB1OC(C)(C)C(C)(C)O1
HCID5017741

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

C9H19BO3

结构：OC1(c2cc(F)cc(F)c2)CCC1
HCID70655171

未命名化合物

结构：[Li]CCCC
HCID178418339

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)OB(c2c(F)cc(C3(O)CCC3)cc2F)OC1(C)C
HCID70655110

1-[3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutanol

C16H21BF2O3

收率 100%

PROCEDURE

实验过程

Method 3 was followed using 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.5 equiv.), butyllithium (2.4 equiv.) and 1-(3,5-difluorophenyl)cyclobutanol (1.0 equiv.) to give 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol in 100% yield. 1H NMR (400 MHz, <cdcl3>) δ ppm 1.23-1.25 (m, 12 H), 1.69-1.82 (m, 1 H), 2.05-2.12 (m, 1 H), 2.37 (br. s., 2 H), 2.47 (br. s., 2 H), 7.00 (d, J=8.80 Hz, 2 H).