4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane → HCID 70655471, compound

HRID 705219Notes

Reaction equation

HRID 705219 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OS(C(F)(F)F)(=O)=O)[CH:5]=[C:4]([F:16])[C:3]=1[C:17]1[N:22]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[CH:20]=[CH:19][C:18]=1[F:27].[CH3:28][C:29]1(C)[C:33](C)(C)OB(C(C)=C)O1>COCCOC>[F:16][C:4]1[CH:5]=[C:6]([C:29]([CH3:33])=[CH2:28])[CH:7]=[C:2]([F:1])[C:3]=1[C:17]1[N:22]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[CH:20]=[CH:19][C:18]=1[F:27]

Participants

4

Reactant 2

HCID 109974264,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolaneHCID 86670164HCID 86670164, compound

Product 1

HCID 70655471HCID 70655471, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
90 °C

Procedure

To a degassed solution of methyl 6-(2,6-difluoro-4-(trifluoromethylsulfonyloxy)phenyl)-5-fluoropicolinate (1.0 equiv.) in DME/2M Na2CO3 (3/1, 0.09 M) was added 4,4,5,5-tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane (1.5 equiv.) and PdCl2(dppf)-CH2Cl2Adduct (0.1 equiv.). The reaction was heated to 90° C. in an oil bath for 15 min. The mixture was cooled to rt and partitioned between water and ethyl acetate. The organic phase was dried with sodium sulfate, filtered and concentrated. The crude material was purified via silica gel column chromatography (Analogix, eluting with 0-100% ethyl acetate). The pure fractions were concentrated to yield methyl 6-(2,6-difluoro-4-(prop-1-en-2-yl)phenyl)-5-fluoropicolinate. LC/MS=308.2 (M+H), Rt=0.99 min. 1H NMR (400 MHz, <cdcl3>) δ ppm 2.15 (s, 3 H), 4.01 (s, 3 H), 5.23 (s, 1 H), 5.47 (s, 1 H), 7.11 (d, J=9.39 Hz, 2 H), 7.65 (t, J=8.41 Hz, 1 H), 8.26 (dd, J=8.61, 3.91 Hz, 1 H).

Workup

  1. temperatureThe mixture was cooled to rt
  2. custompartitioned between water and ethyl acetate
  3. dry with materialThe organic phase was dried with sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crude material was purified via silica gel column chromatography (Analogix, eluting with 0-100% ethyl acetate)
  7. concentrationThe pure fractions were concentrated

Sources & evidence

ORD record
ord-1219f31efe65475e99e1065ed7fbb49e
Source dataset
uspto-grants-2015_11
Patent number
US09173883B2

Reaction notes

Loading…