反应详情

To a solution of tert-butyl (1R,2R,3S,5R)-5-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-2-hydroxy-3-methylcyclohexylcarbamate (1.0 equiv.) in DCM (0.10 M) was added Dess-MartinPeriodinane (1.2 equiv.). The flask was capped and the homogeneous solution was left stirring at rt for 3 hrs. The solution was partitioned between EtOAc and 1:1 10% Na2S2O3/NaHCO3 (sat.). The organic layer was washed with NaCl(sat.), dried over MgSO4, filtered and concentrated, and purified by ISCO SiO2 chromatography to yield tert-butyl (1R,3S,5R)-5-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-3-methyl-2-oxocyclohexylcarbamate in 83% yield. LC/MS (m/z)=555.4 (MH+), Rt=0.87 min.

1. customThe flask was capped
2. waitthe homogeneous solution was left
3. customThe solution was partitioned between EtOAc and 1:1 10% Na2S2O3/NaHCO3 (sat.)
4. washThe organic layer was washed with NaCl(sat.)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated
8. custompurified by ISCO SiO2 chromatography