HRID705295

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCO[C@H]1[C@@H](C)CC(c2ccncc2[N+](=O)[O-])=C[C@H]1NC(=O)OC(C)(C)C

HCID86705257

未命名化合物

PRODUCTS

生成物

HCID276

Carbamic acid, ion(1-)

CH2NO2-

收率 33%

结构：CCO[C@H]1[C@@H](C)C[C@@H](c2ccncc2N)C[C@H]1NC(=O)OC(C)(C)C

HCID86705259

未命名化合物

收率 28%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22502148

未命名化合物

PROCEDURE

实验过程

Method 6 was followed using (+/−)-tert-butyl (1R,5S,6S)-6-ethoxy-5-methyl-3-(3-nitropyridin-4-yl)cyclohex-2-enylcarbamate with Chiral HPLC (Heptane/EtOH=90/10, 20 mL/min, IC column) to yield tert-butyl a 1S,2R,3R,5S)-5-(3-aminopyridin-4-yl)-2-ethoxy-3-methylcyclohexyl)carbamate (33% yield, 99% ee) and tert-butyl ((1R,2S,3S,5R)-5-(3-aminopyridin-4-yl)-2-ethoxy-3-methylcyclohexyl)carbamate (28% yield, 99% ee). LC/MS (m/z)=350.2 (MH+), Rt=0.72 min.