反应详情

To a solution of crude (S)-1-chloro-3-(4-(2-(4-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propan-2-yl)phenoxy)propan-2-yl acetate in anhydrous acetonitrile (8.0 mL) was added bismuth triflate (300 mg, 0.46 mmol) in one portion. After 0.5 h, the reaction mixture was partitioned twice with sodium bicarbonate and ethyl acetate. The organic phased were combined, dried over anhydrous magnesium sulfate, and filtered. Solvents were evaporated, and the resulting crude material was purified by silica gel flash chromatography (eluent: 2% to 5% methanol in dichloromethane) to provide the title compound (734 mg, 86%) as a sticky solid.

1. customthe reaction mixture was partitioned twice with sodium bicarbonate and ethyl acetate
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationfiltered
4. customSolvents were evaporated
5. customthe resulting crude material was purified by silica gel flash chromatography (eluent: 2% to 5% methanol in dichloromethane)