Potassium Carbonate → HCID 178490930, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1N using the imidazoline prepared in Example 2A (0.816 g, 1.49 mmol), anhydrous dimethyl sulfoxide (7.5 mL), powdered potassium carbonate (0.412 g, 2.98 mmol) and iodobenzene diacetate (0.528 g, 1.639 mmol) giving the title compound as a tan solid (0.65 g, 71%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.19-0.41 (m, 1H) 0.64-1.02 (m, 2H) 2.18-2.32 (m, 2H) 2.37 (s, 3H) 3.23 (s, 3H) 3.68 (s, 3H) 4.67-4.79 (m, 1H) 4.81-4.97 (m, 1H) 6.80 (d, J=8.82 Hz, 2H) 6.98 (s, 1H) 7.07-7.25 (m, 2H) 7.33-7.49 (m, 2H) 7.54-7.74 (m, 3H) 7.92 (s, 1H) 14.47 (s, 1H); MS (ESI+) m/z 546.1 (M+H)+, (ESI−) 544.1 (M−H)−.

Provenance & Evidence